ParkinsonCanadaV1, Main, Exploration, bibRecord, 001239

Essential tremor is not a neurodegenerative disease

Identifieur interne : 001239 ( Main/Exploration ); précédent : 001238; suivant : 001240

Essential tremor is not a neurodegenerative disease

Auteurs : Ali H. Rajput [Canada] ; Charles H. Adler [États-Unis] ; Holly A. Shill [États-Unis] ; Alex Rajput [Canada]

Source :

Neurodegenerative disease management [ 1758-2024 ] ; 2012.

RBID : PMC:3478956

Abstract

SUMMARY

The pathophysiology of essential tremor (ET) remains unknown. Standard neuropathological studies have reported no consistent changes but a detailed study found neurodegeneration in all ET cases – 24% demonstrated lower brainstem Lewy body (LB) inclusions and 76% experienced a loss of cerebellar Purkinje cells (PCs) and its sequelae. We review the evidence on neurodegeneration in ET. The prevalence of LB inclusions in ET brains is similar to that in the asymptomatic general population. These incidental LB disease cases have evidence for reduced striatal tyrosine hydroxylase levels, as found in Parkinson’s disease, but there is no evidence for reduced tyrosine hydroxylase levels in ET patients. Reduced mean PC counts in ET cases compared with the controls reported by some studies could not be replicated by others. Most ET cases have the same number of PCs as controls of a comparable age. Neither the lower brainstem LB inclusions nor the cerebellar PC loss represent the neurodegenerative basis of ET. Further studies are needed to determine the pathophysiology of ET.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478956

DOI: 10.2217/nmt.12.23
PubMed: 23105950
PubMed Central: 3478956

Affiliations:

Canada, États-Unis

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La maladie de Parkinson au Canada (serveur d'exploration)

Essential tremor is not a neurodegenerative disease

Essential tremor is not a neurodegenerative disease

Source :

Abstract

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	La maladie de Parkinson au Canada (serveur d'exploration)
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